AZIN2

AZIN2
Identifikatori
Aliasi	AZIN2
Vanjski ID-jevi	OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	33,123,492 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	128,856,235 bp
Ontologija gena
Molekularna funkcija	• putrescine transmembrane transporter activity; • catalytic activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ornithine decarboxylase activator activity; • arginine decarboxylase activity; • ornithine decarboxylase activity;
Ćelijska komponenta	• transport vesicle; • citoplazma; • mitohondrija; • trans-Golđijeva mreža; • projekcija ćelije; • Golđijev aparat; • jedro; • Akson; • granular vesicle; • membrana; • dendrit; • perinuklearno područje citoplazme; • cis-Golgi network; • GO:0016023 citoplazmatska vezikula; • perikaryon; • endoplasmic reticulum-Golgi intermediate compartment membrane; • endoplasmic reticulum-Golgi intermediate compartment; • citosol;
Biološki proces	• positive regulation of polyamine transmembrane transport; • Spermatogeneza; • putrescine transport; • ornithine metabolic process; • putrescine biosynthetic process from ornithine; • trans-Golgi network membrane organization; • agmatine biosynthetic process; • GO:0048554 positive regulation of catalytic activity; • polyamine biosynthetic process; • GO:1903363 negative regulation of protein catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	113451
	242669
	ENSG00000142920
	ENSMUSG00000028789
	Q96A70
	Q8BVM4
NM_001293562; NM_001301823; NM_001301824; NM_001301825; NM_001301826;
	NM_052998; NM_001350398; NM_001350399; NM_001350400; NM_001350401; NM_001350402; NM_001376722; NM_001376724; NM_001376725; NM_001376727; NM_001376729; NM_001376730; NM_001376732
	NM_001301841; NM_172875
NP_001280491; NP_001288752; NP_001288753; NP_001288754; NP_001288755;
	NP_443724; NP_001337327; NP_001337328; NP_001337329; NP_001337330; NP_001337331; NP_001363651; NP_001363653; NP_001363654; NP_001363656; NP_001363658; NP_001363659; NP_001363661
	NP_001288770; NP_766463
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Antizimski inhibitor 2 (AzI2) znan i kao arginin-dekarboksilaza (ADC) jest enzim koji je kod ljudi kodiran genom AZIN2 sa hromosoma 1. .^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 460 aminokiselina, a molekulska težina 49.980 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGYLSESDF	VMVEEGFSTR	DLLKELTLGA	SQATTDEVAA	FFVADLGAIV
RKHFCFLKCL	PRVRPFYAVK	CNSSPGVLKV	LAQLGLGFSC	ANKAEMELVQ
HIGIPASKII	CANPCKQIAQ	IKYAAKHGIQ	LLSFDNEMEL	AKVVKSHPSA
KMVLCIATDD	SHSLSCLSLK	FGVSLKSCRH	LLENAKKHHV	EVVGVSFHIG
SGCPDPQAYA	QSIADARLVF	EMGTELGHKM	HVLDLGGGFP	GTEGAKVRFE
EIASVINSAL	DLYFPEGCGV	DIFAELGRYY	VTSAFTVAVS	IIAKKEVLLD
QPGREEENGS	TSKTIVYHLD	EGVYGIFNSV	LFDNICPTPI	LQKKPSTEQP
LYSSSLWGPA	VDGCDCVAEG	LWLPQLHVGD	WLVFDNMGAY	TVGMGSPFWG
TQACHITYAM	SRVAWEALRR	QLMAAEQEDD	VEGVCKPLSC	GWEITDTLCV
GPVFTPASIM

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
^ Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.
^ "Entrez Gene: ADC arginine decarboxylase".
^ "UniProt, Q96A70" (jezik: engleski). Pristupljeno 21. 11. 2021.

Dopunska literatura

Nagase T, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Coleman CS, Hu G, Pegg AE (2004). "Putrescine biosynthesis in mammalian tissues". Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". Int. J. Cancer. 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase". Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.

Vanjski linkovi

Lokacija ljudskog genoma AZI2 i stranica sa detaljima o genu AZI2 u UCSC Genome Browseru.
Lokacija ljudskog genoma AZIN2 i stranica sa detaljima o genu AZIN2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11587527-5] Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.

[pmid14738999-6] Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta. 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMC 3118518. PMID 14738999.

[entrez-7] "Entrez Gene: ADC arginine decarboxylase".

[UniProt-8] "UniProt, Q96A70" (jezik: engleski). Pristupljeno 21. 11. 2021.

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