TGOLN2
Integralni membranski protein 2 trans-Golgijeve mreže jest protein koji je kod ljudi kodiran genom TGOLN2 sa hromosoma 2.[3][4]
Amiokiselininska sekvenca uredi
Dužina polipeptidnog lanca je 480 aminokiselina, a molekulska težina 51.113 Da.[5]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRFVVALVLL | NVAAAGAVPL | LATESVKQEE | AGVRPSAGNV | STHPSLSQRP | ||||
| GGSTKSHPEP | QTPKDSPSKS | SAEAQTPEDT | PNKSGAEAKT | QKDSSNKSGA | ||||
| EAKTQKGSTS | KSGSEAQTTK | DSTSKSHPEL | QTPKDSTGKS | GAEAQTPEDS | ||||
| PNRSGAEAKT | QKDSPSKSGS | EAQTTKDVPN | KSGADGQTPK | DGSSKSGAED | ||||
| QTPKDVPNKS | GAEKQTPKDG | SNKSGAEEQG | PIDGPSKSGA | EEQTSKDSPN | ||||
| KVVPEQPSRK | DHSKPISNPS | DNKELPKADT | NQLADKGKLS | PHAFKTESGE | ||||
| ETDLISPPQE | EVKSSEPTED | VEPKEAEDDD | TGPEEGSPPK | EEKEKMSGSA | ||||
| SSENREGTLS | DSTGSEKDDL | YPNGSGNGSA | ESSHFFAYLV | TAAILVAVLY | ||||
| IAHHNKRKII | AFVLEGKRSK | VTRRPKASDY | QRLDQKYVLI | LNVFPAPPKR | ||||
| SFLPQVLTEW | YIPLEKDERH | QWIVLLSFQL |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000152291 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi:10.1074/jbc.273.2.981. PMID 9422759.
- ^ "Entrez Gene: TGOLN2 trans-golgi network protein 2".
- ^ "UniProt, O43493" (jezik: engleski). Pristupljeno 14. 11. 2021.
Dopunska literatura uredi
- Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Ponnambalam S, Girotti M, Yaspo ML, et al. (1997). "Primate homologues of rat TGN38: primary structure, expression and functional implications". J. Cell Sci. 109 (3): 675–85. doi:10.1242/jcs.109.3.675. PMID 8907712.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (Pt 3): 567–72. doi:10.1042/bj3350567. PMC 1219817. PMID 9794796.
- Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
- Wang J, Howell KE (2001). "The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking". Traffic. 1 (9): 713–23. doi:10.1034/j.1600-0854.2000.010904.x. PMID 11208159. S2CID 22784729.
- Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yeaman C, Ayala MI, Wright JR, et al. (2004). "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network". Nat. Cell Biol. 6 (2): 106–12. doi:10.1038/ncb1090. PMC 3372901. PMID 14743217.
- Höning S, Ricotta D, Krauss M, et al. (2005). "Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2" (PDF). Mol. Cell. 18 (5): 519–31. doi:10.1016/j.molcel.2005.04.019. hdl:11379/18706. PMID 15916959.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.