RSF1
Faktor 1 remodeliranja i razmicanja je protein koji je kod ljudi kodiran genom RSF1.[5][6][7]
HBXAP je uključen u represiju transkripcije), koaktivaciju transkripcije kada je povezan s virusom hepatitisa B, a X proteinom (HBX) i hromatinskim remodeliranjem i razmakom kada je povezan sa SNF2H (MIM 603375603375; prema OMIM.[7]
Aminokiaelinska sekvenca uredi
Dužina polipeptidnog lanca je 1.441 aminokiselina, а molekulska težina 163.821 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MATAAAAAAV | MAPPGCPGSC | PNFAVVCSFL | ERYGPLLDLP | ELPFPELERV | ||||
| LQAPPPDVGN | GEVPKELVEL | HLKLMRKIGK | SVTADRWEKY | LIKICQEFNS | ||||
| TWAWEMEKKG | YLEMSVECKL | ALLKYLCECQ | FDDNLKFKNI | INEEDADTMR | ||||
| LQPIGRDKDG | LMYWYQLDQD | HNVRMYIEEQ | DDQDGSSWKC | IVRNRNELAE | ||||
| TLALLKAQID | PVLLKNSSQQ | DNSSRESPSL | EDEETKKEEE | TPKQEEQKES | ||||
| EKMKSEEQPM | DLENRSTANV | LEETTVKKEK | EDEKELVKLP | VIVKLEKPLP | ||||
| ENEEKKIIKE | ESDSFKENVK | PIKVEVKECR | ADPKDTKSSM | EKPVAQEPER | ||||
| IEFGGNIKSS | HEITEKSTEE | TEKLKNDQQA | KIPLKKREIK | LSDDFDSPVK | ||||
| GPLCKSVTPT | KEFLKDEIKQ | EEETCKRIST | ITALGHEGKQ | LVNGEVSDER | ||||
| VAPNFKTEPI | ETKFYETKEE | SYSPSKDRNI | ITEGNGTESL | NSVITSMKTG | ||||
| ELEKETAPLR | KDADSSISVL | EIHSQKAQIE | EPDPPEMETS | LDSSEMAKDL | ||||
| SSKTALSSTE | SCTMKGEEKS | PKTKKDKRPP | ILECLEKLEK | SKKTFLDKDA | ||||
| QRLSPIPEEV | PKSTLESEKP | GSPEAAETSP | PSNIIDHCEK | LASEKEVVEC | ||||
| QSTSTVGGQS | VKKVDLETLK | EDSEFTKVEM | DNLDNAQTSG | IEEPSETKGS | ||||
| MQKSKFKYKL | VPEEETTASE | NTEITSERQK | EGIKLTIRIS | SRKKKPDSPP | ||||
| KVLEPENKQE | KTEKEEEKTN | VGRTLRRSPR | ISRPTAKVAE | IRDQKADKKR | ||||
| GEGEDEVEEE | STALQKTDKK | EILKKSEKDT | NSKVSKVKPK | GKVRWTGSRT | ||||
| RGRWKYSSND | ESEGSGSEKS | SAASEEEEEK | ESEEAILADD | DEPCKKCGLP | ||||
| NHPELILLCD | SCDSGYHTAC | LRPPLMIIPD | GEWFCPPCQH | KLLCEKLEEQ | ||||
| LQDLDVALKK | KERAERRKER | LVYVGISIEN | IIPPQEPDFS | EDQEEKKKDS | ||||
| KKSKANLLER | RSTRTRKCIS | YRFDEFDEAI | DEAIEDDIKE | ADGGGVGRGK | ||||
| DISTITGHRG | KDISTILDEE | RKENKRPQRA | AAARRKKRRR | LNDLDSDSNL | ||||
| DEEESEDEFK | ISDGSQDEFV | VSDENPDESE | EDPPSNDDSD | TDFCSRRLRR | ||||
| HPSRPMRQSR | RLRRKTPKKK | YSDDDEEEES | EENSRDSESD | FSDDFSDDFV | ||||
| ETRRRRSRRN | QKRQINYKED | SESDGSQKSL | RRGKEIRRVH | KRRLSSSESE | ||||
| ESYLSKNSED | DELAKESKRS | VRKRGRSTDE | YSEADEEEEE | EEGKPSRKRL | ||||
| HRIETDEEES | CDNAHGDANQ | PARDSQPRVL | PSEQESTKKP | YRIESDEEED | ||||
| FENVGKVGSP | LDYSLVDLPS | TNGQSPGKAI | ENLIGKPTEK | SQTPKDNSTA | ||||
| SASLASNGTS | GGQEAGAPEE | EEDELLRVTD | LVDYVCNSEQ | L |
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000048649 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035623 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
- ^ Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
- ^ a b "Entrez Gene: RSF1 remodeling and spacing factor 1".
- ^ "UniProt, Q96T23". Pristupljeno 26. 8. 2021.
Dopunska literatura uredi
- Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". J. Virol. 69 (2): 1107–14. doi:10.1128/JVI.69.2.1107-1114.1995. PMC 188683. PMID 7815490.
- LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
- Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity". Genomics. 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
- Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.