PDGFB

PDGFB
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Identifikatori
Aliasi	PDGFB
Vanjski ID-jevi	OMIM: 190040 MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	39,244,982 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	80,014,977 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • protein heterodimerization activity; • chemoattractant activity; • platelet-derived growth factor receptor binding; • platelet-derived growth factor binding; • superoxide-generating NADPH oxidase activator activity; • growth factor activity; • vezivanje identičnih proteina; • collagen binding; • GO:0001948, GO:0016582 vezivanje za proteine; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Ćelijska komponenta	• platelet alpha granule lumen; • citoplazma; • extracellular region; • Golđijeva membrana; • basolateral plasma membrane; • cell surface; • endoplasmic reticulum lumen; • membrana; • GO:0005578 Vanćelijski matriks; • Vanćelijsko; • Golgi lumen; • collagen-containing extracellular matrix;
Biološki proces	• activation of protein kinase B activity; • positive regulation of DNA biosynthetic process; • positive regulation of chemotaxis; • cellular response to growth factor stimulus; • positive regulation of protein tyrosine kinase activity; • peptidyl-tyrosine phosphorylation; • positive regulation of cell division; • heart development; • positive regulation of glomerular filtration; • positive regulation of mitotic nuclear division; • positive regulation of MAP kinase activity; • positive regulation of metanephric mesenchymal cell migration; • positive regulation of hyaluronan biosynthetic process; • MAPK cascade; • protein phosphorylation; • positive regulation of glomerular mesangial cell proliferation; • cellular response to mycophenolic acid; • positive regulation of fibroblast proliferation; • activation of protein kinase activity; • multicellular organism development; • positive regulation of protein autophosphorylation; • positive regulation of reactive oxygen species metabolic process; • reactive oxygen species metabolic process; • GO:0045996 negative regulation of transcription, DNA-templated; • protein kinase C signaling; • metanephric glomerular mesangial cell development; • negative regulation of phosphatidylinositol biosynthetic process; • response to wounding; • positive regulation of phosphatidylinositol 3-kinase activity; • cell chemotaxis; • positive regulation of ERK1 and ERK2 cascade; • platelet degranulation; • positive regulation of cell population proliferation; • positive regulation of DNA replication; • GO:1901313 positive regulation of gene expression; • embryonic placenta development; • paracrine signaling; • monocyte chemotaxis; • positive regulation of endothelial cell proliferation; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of calcium ion import; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; • positive regulation of blood vessel endothelial cell migration; • Hematopoeza; • positive regulation of cell migration; • positive regulation of peptidyl-tyrosine phosphorylation; • extracellular matrix organization; • negative regulation of protein binding; • positive regulation of MAPK cascade; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of platelet activation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of vascular associated smooth muscle cell migration; • positive chemotaxis; • negative regulation of vascular associated smooth muscle cell differentiation; • interleukin-18-mediated signaling pathway; • positive regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of gene expression; • positive regulation of smooth muscle cell migration; • positive regulation of smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell dedifferentiation; • platelet-derived growth factor receptor signaling pathway; • positive regulation of vascular associated smooth muscle cell proliferation; • negative regulation of platelet-derived growth factor receptor-beta signaling pathway; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	5155
	18591
	ENSG00000100311
	ENSMUSG00000000489
	P01127
	P31240
	NM_033016; NM_002608
	NM_011057
	NP_002599; NP_148937
	NP_035187
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica B trombocitno-izvedenog faktora rasta jest protein koji je kod ljudi kodiran genom PDGFB sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 241 aminokiselina, a molekulska težina 27.283 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNRCWALFLS	LCCYLRLVSA	EGDPIPEELY	EMLSDHSIRS	FDDLQRLLHG
DPGEEDGAEL	DLNMTRSHSG	GELESLARGR	RSLGSLTIAE	PAMIAECKTR
TEVFEISRRL	IDRTNANFLV	WPPCVEVQRC	SGCCNNRNVQ	CRPTQVQLRP
VQVRKIEIVR	KKPIFKKATV	TLEDHLACKC	ETVAAARPVT	RSPGGSQEQR
AKTPQTRVTI	RTVRVRRPPK	GKHRKFKHTH	DKTALKETLG	A

Funkcija uredi

Protein kodiran ovim genom je član porodice trombocitnih faktora rasta. Četiri člana ove porodice su mitogeni faktori za ćelije mezenhimskog porijekla i karakteriše ih motiv od osam cisteina. Ovaj genski proizvod može postojati ili kao homodimer (PDGF-BB) ili kao heterodimer sa polipeptidnim faktorom rasta alfa (PDGFA) koji potiče od trombocita (PDGF-AB), gdje su dimeri povezani disulfidnim vezama.

Klinički značaj uredi

Mutacije ovog gena povezane su sa meningiomom. Recipročne translokacije između hromozoma 22 i 17, na mjestima gdje su locirani geni PDGFB i COL1A1 ili, alternativno, abnormalni mali prekobrojni prstenasti hromosom spajaju ova dva gena u formiraju COL1A-PDGFB fuzijski gen. Ovaj fuzijski gen u velikoj mjeri prekomjerno proizvodi PDGFB i smatra se odgovornim za izazivanje razvoja i/ili progresije tri blisko povezana fibroblastna i miofibroblastna tumora kože: fibroblastom divovskih ćelija, dermatofibrosarcoma protuberans i sarkomski dermatofibrosarkom protuberans.^[7]

Za gen PDGFB, identificirane su dvije prerađene varijante transkripta.^[8]

Također pogledajte uredi

Trombocitni faktor rasta

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100311 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000489 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848.
^ ^a ^b Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670.
^ Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43–58. doi:10.1007/s12105-019-01104-3. PMC 7021862. PMID 31950474.
^ "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)".

Dopunska literatura uredi

Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.

Vanjski linkovi uredi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100311 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000489 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2991848-5] Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848.

[pmid1661670-6] Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670.

[pmid31950474-7] Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43–58. doi:10.1007/s12105-019-01104-3. PMC 7021862. PMID 31950474.

[8] "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)".

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