LARS2
Vjerovatna mitohondrijska leucl-tRNK sintetaza jest enzim koji je kod ljudi kodiran genom LARS2 sa hromosoma 3.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 903 aminokiseline, а molekulska težina 101.976 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASVWQRLGF | YASLLKRQLN | GGPDVIKWER | RVIPGCTRSI | YSATGKWTKE | ||||
| YTLQTRKDVE | KWWHQRIKEQ | ASKISEADKS | KPKFYVLSMF | PYPSGKLHMG | ||||
| HVRVYTISDT | IARFQKMRGM | QVINPMGWDA | FGLPAENAAV | ERNLHPQSWT | ||||
| QSNIKHMRKQ | LDRLGLCFSW | DREITTCLPD | YYKWTQYLFI | KLYEAGLAYQ | ||||
| KEALVNWDPV | DQTVLANEQV | DEHGCSWRSG | AKVEQKYLRQ | WFIKTTAYAK | ||||
| AMQDALADLP | EWYGIKGMQA | HWIGDCVGCH | LDFTLKVHGQ | ATGEKLTAYT | ||||
| ATPEAIYGTS | HVAISPSHRL | LHGHSSLKEA | LRMALVPGKD | CLTPVMAVNM | ||||
| LTQQEVPVVI | LAKADLEGSL | DSKIGIPSTS | SEDTILAQTL | GLAYSEVIET | ||||
| LPDGTERLSS | SAEFTGMTRQ | DAFLALTQKA | RGKRVGGDVT | SDKLKDWLIS | ||||
| RQRYWGTPIP | IVHCPVCGPT | PVPLEDLPVT | LPNIASFTGK | GGPPLAMASE | ||||
| WVNCSCPRCK | GAAKRETDTM | DTFVDSAWYY | FRYTDPHNPH | SPFNTAVADY | ||||
| WMPVDLYIGG | KEHAVMHLFY | ARFFSHFCHD | QKMVKHREPF | HKLLAQGLIK | ||||
| GQTFRLPSGQ | YLQREEVDLT | GSVPVHAKTK | EKLEVTWEKM | SKSKHNGVDP | ||||
| EEVVEQYGID | TIRLYILFAA | PPEKDILWDV | KTDALPGVLR | WQQRLWTLTT | ||||
| RFIEARASGK | SPQPQLLSNK | EKAEARKLWE | YKNSVISQVT | THFTEDFSLN | ||||
| SAISQLMGLS | NALSQASQSV | ILHSPEFEDA | LCALMVMAAP | LAPHVTSEIW | ||||
| AGLALVPRKL | CAHYTWDASV | LLQAWPAVDP | EFLQQPEVVQ | MAVLINNKAC | ||||
| GKIPVPQQVA | RDQDKVHEFV | LQSELGVRLL | QGRSIKKSFL | SPRTALINFL | ||||
| VQD |
Funkcija uredi
Ovaj gen kodira klasa 1 aminoacil-tRNA sintetaze, mitohondrijjske leucil-tRNK sintetaze. Svaka od dvadeset aminoacil-tRNA sintetaza katalizira aminoacilaciju specifične tRNK ili tRNK izoakceptirajuće porodice sa srodnom amino kiselinom.[7]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000011376 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035202 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sohm B, Sissler M, Park H, King MP, Florentz C (maj 2004). "Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase". J Mol Biol. 339 (1): 17–29. doi:10.1016/j.jmb.2004.03.066. PMID 15123417.
- ^ "UniProt, Q15031" (jezik: engleski). Pristupljeno 4. 11. 2021.
- ^ "Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial".
Dopunska literatura uredi
- Olsson P, Wennberg AL (1992). "[Midwife and research. Conference report]". Jordemodern. 104 (11): 408–9, 404. PMID 1684970.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
- Szeles A, Yang Y, Sandlund AM, et al. (1998). "Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM". Genes Chromosomes Cancer. 20 (4): 329–36. doi:10.1002/(SICI)1098-2264(199712)20:4<329::AID-GCC3>3.0.CO;2-3. PMID 9408748.
- Kiss H, Kedra D, Yang Y, et al. (2000). "A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3". Hum. Genet. 105 (6): 552–9. doi:10.1007/s004390051144. PMID 10647888.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yao YN, Wang L, Wu XF, Wang ED (2004). "The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells". FEBS Lett. 534 (1–3): 139–42. doi:10.1016/S0014-5793(02)03833-4. PMID 12527375. S2CID 21901003.
- Park H, Davidson E, King MP (2003). "The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation". Biochemistry. 42 (4): 958–64. doi:10.1021/bi026882r. PMID 12549915.
- Yao YN, Wang L, Wu XF, Wang ED (2004). "Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli". Protein Expr. Purif. 30 (1): 112–6. doi:10.1016/S1046-5928(03)00097-4. PMID 12821328.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Munakata K, Iwamoto K, Bundo M, Kato T (2005). "Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia". Biol. Psychiatry. 57 (5): 525–32. doi:10.1016/j.biopsych.2004.11.041. PMID 15737668. S2CID 28499960.
- 't Hart LM, Hansen T, Rietveld I, et al. (2005). "Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene". Diabetes. 54 (6): 1892–5. doi:10.2337/diabetes.54.6.1892. PMID 15919814.