UTY

(Preusmjereno sa KDM6AL)

Histonska demetilaza UTY je enzim koji je kod ljudi kodiran genom UTY.[3][4][5]

UTY
Dostupne strukture
PDBPretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova

3ZLI, 3ZPO, 4UF0, 5FY0, 5FXW, 5FXX, 5FXZ, 5FY1, 5FY7, 5FYM, 5FXV, 5A1L

Identifikatori
AliasiUTY
Vanjski ID-jeviOMIM: 400009 GeneCards: UTY
Lokacija gena (čovjek)
Hromosom Y
Hrom.Hromosom Y[1]
Hromosom Y
Genomska lokacija za UTY
Genomska lokacija za UTY
BendYq11.221Početak13,234,577 bp[1]
Kraj13,480,673 bp[1]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija oxidoreductase activity
dioxygenase activity
histone H3-tri/di-methyl-lysine-27 demethylase activity
vezivanje iona metala
histone demethylase activity
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
chromatin binding
chromatin DNA binding
sequence-specific DNA binding
Ćelijska komponenta jedro
nukleoplazma
MLL3/4 complex
Biološki proces Regulacija ekspresije gena
histone H3-K27 demethylation
GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001258249
NM_001258250
NM_001258251
NM_001258252
NM_001258253

NM_001258254
NM_001258255
NM_001258256
NM_001258257
NM_001258258
NM_001258259
NM_001258260
NM_001258261
NM_001258262
NM_001258263
NM_001258264
NM_001258265
NM_001258266
NM_001258267
NM_001258268
NM_001258269
NM_001258270
NM_007125
NM_182659
NM_182660
NM_001400170
NM_001400171
NM_001400173
NM_001400175
NM_001400177
NM_001400178
NM_001400181
NM_001400183
NM_001400185
NM_001400187
NM_001400189
NM_001400192
NM_001400195
NM_001400199

n/a

RefSeq (bjelančevina)
NP_001245178
NP_001245179
NP_001245180
NP_001245181
NP_001245182

NP_001245183
NP_001245184
NP_001245185
NP_001245186
NP_001245187
NP_001245188
NP_001245189
NP_001245190
NP_001245191
NP_001245192
NP_001245193
NP_001245194
NP_001245195
NP_001245196
NP_001245197
NP_001245198
NP_001245199
NP_009056
NP_872600
NP_872601
NP_001245196.1
NP_001245192.1
NP_001245178.1
NP_001245194.1
NP_001245186.1
NP_001245191.1
NP_001245187.1

n/a

Lokacija (UCSC)Chr Y: 13.23 – 13.48 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Ovaj gen kodira protein koji sadrži tetratrikopeptid-ponavljanje za koji se smatra da je uključen u interakcije protein-protein. Manji je antigen histokompatibilnost, koji može inducirati odbacivanje transplantata presađenih muških matičnih ćelija. Alternativna prerada RNK rezultira u više varijanti transkripta koji kodiraju različite izoforme.[5]

Interakcije

uredi

Pokazano je da UTY ima interakcije sa TLE1 [6] i WDR90.[7]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183878 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, et al. (decembar 1996). "An H-YDb epitope is encoded by a novel mouse y chromosome gene". nature genetics. 14 (4): 474–8. doi:10.1038/ng1296-474. PMID 8944031.
  4. ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, et al. (april 1998). "The UTX gene escapes X inactivation in mice and humans". Human Molecular Genetics. 7 (4): 737–42. doi:10.1093/hmg/7.4.737. PMID 9499428.
  5. ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked".
  6. ^ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (januar 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 ( Pt 1) (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
  7. ^ "STRING: functional protein association networks". string-db.org. Pristupljeno 7. 5. 2015.

Dopunska literatura

uredi