Janus-kinaza 1 jest enzim koji je kod ljudi kodiran genom JAK1 sa hromosoma 1.

JAK1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI

Identifikatori
AliasiJAK1
Vanjski ID-jeviOMIM: 147795 MGI: 96628 HomoloGene: 1678 GeneCards: JAK1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za JAK1
Genomska lokacija za JAK1
Bend1p31.3Početak64,833,229 bp[1]
Kraj65,067,754 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za JAK1
Genomska lokacija za JAK1
Bend4 C6|4 46.19 cMPočetak101,152,367 bp[2]
Kraj101,265,282 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija aktivnost sa transferazom
nucleotide binding
protein kinase activity
CCR5 chemokine receptor binding
growth hormone receptor binding
vezivanje iona metala
kinase activity
GO:0001948, GO:0016582 vezivanje za proteine
protein tyrosine kinase activity
protein phosphatase binding
signaling receptor binding
ATP binding
ubiquitin protein ligase binding
non-membrane spanning protein tyrosine kinase activity
Ćelijska komponenta citoplazma
citosol
membrana
focal adhesion
extrinsic component of cytoplasmic side of plasma membrane
citoskelet
Endomembranski sistem
jedro
endozom
Biološki proces Ćelijska diferencijacija
GO:0007243 intracellular signal transduction
Fosforilacija
transmembrane receptor protein tyrosine kinase signaling pathway
interferon-gamma-mediated signaling pathway
GO:1904576 response to antibiotic
MAPK cascade
positive regulation of sprouting angiogenesis
protein phosphorylation
regulation of type I interferon-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
regulation of cell population proliferation
type I interferon signaling pathway
interleukin-2-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
protein autophosphorylation
Ćelijska migracija
Urođeni imunski sistem
interleukin-12-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-15-mediated signaling pathway
interleukin-9-mediated signaling pathway
regulation of molecular function
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
interleukin-21-mediated signaling pathway
interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
interleukin-35-mediated signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_002227
NM_001320923
NM_001321852
NM_001321853
NM_001321854

NM_001321855
NM_001321856
NM_001321857

NM_146145
NM_013567

RefSeq (bjelančevina)
NP_001307852
NP_001308781
NP_001308782
NP_001308783
NP_001308784

NP_001308785
NP_001308786
NP_002218

n/a

Lokacija (UCSC)Chr 1: 64.83 – 65.07 MbChr 4: 101.15 – 101.27 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.154 aminokiseline, a molekulska težina 133.277 Da.[5]

1020304050
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRL
GSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDK
MSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLL
DASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHY
AMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKE
FNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKH
KKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHE
EALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAI
NKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI
EVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPRE
ISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHI
VYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLAS
ALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQ
ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLI
EKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEE
QNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGN
GIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYV
HRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAP
ECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMT
VTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFE
ALLK

Funkcija

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Janus-kinaza je ljudska tirozin-kinaza, protein neophodan za signalizaciju određenih tipova I i tipa II citokina. Stupa u interakciju sa zajedničkim gama lancem (γc) citokinskog receptora tipa I, da izazove signale iz porodice IL-2 receptora (npr. IL -2R, IL-7R, IL-9R i IL-15R), IL-4 porodica receptora (npr. IL-4R i IL-13R), porodica gp130 receptora (npr. IL-6R , IL-11R, LIF-R, OSM-R, kardiotrofin-1 receptor (CT-1R), cilijarni neurotrofni faktor receptor (CNTF-R), neurotrofin-1 receptor (NNT-1R) i leptin-R). Također je važan za transdukciju signala po tipu I (IFN-α/β) i tipu II (IFN-γ) interferona, i članovima porodice IL-10 preko citokinskih receptora tipa II.[6] Jak1 ima ključnu ulogu u pokretanju odgovora na višestruke velike porodice citokinskih receptora. Gubitak Jak1 je smrtonosan kod neonatusih miševa, vjerovatno zbog poteškoća u sisanju.[7] Ekspresija gena JAK1 u ćelijama raka omogućava pojedinačnim ćelijama da se kontrahuju, potencijalno im omogućavajući da pobegnu od tumora i metastaziraju u druge dijelove tijela.[8]

Interakcije

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Pokazalo se da je Janus-kinaza 1 u interakciji sa:

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162434 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028530 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UniProt, P23458" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
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  9. ^ Collum RG, Brutsaert S, Lee G, Schindler C (august 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
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  19. ^ Zhu MH, Berry JA, Russell SM, Leonard WJ (april 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta". J. Biol. Chem. 273 (17): 10719–25. doi:10.1074/jbc.273.17.10719. PMID 9553136.
  20. ^ Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (novembar 1998). "Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation". Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC 109227. PMID 9774657.
  21. ^ Gual P, Baron V, Lequoy V, Van Obberghen E (mart 1998). "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". Endocrinology. 139 (3): 884–93. doi:10.1210/endo.139.3.5829. PMID 9492017.
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  23. ^ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (decembar 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. 277 (50): 48220–6. doi:10.1074/jbc.M205757200. PMID 12374810.
  24. ^ Yin T, Shen R, Feng GS, Yang YC (januar 1997). "Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases". J. Biol. Chem. 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. PMID 8995399.
  25. ^ Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (januar 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130". J. Biol. Chem. 278 (1): 661–71. doi:10.1074/jbc.M210552200. PMID 12403768.
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Dopunska literatura

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Vanjski linkovi

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Šablon:Modulator citokinskih receptora