CNBP

(Preusmjereno sa DM2)

Ćelijski i protein koji veže nukleinsku kiselinu je protein koji je kod je ljudi kodiran genom CNBP.[5][6][7]

CNBP
Identifikatori
AliasiCNBP
Vanjski ID-jeviOMIM: 116955 MGI: 88431 HomoloGene: 2567 GeneCards: CNBP
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za CNBP
Genomska lokacija za CNBP
Bend3q21.3Početak129,167,827 bp[1]
Kraj129,183,922 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za CNBP
Genomska lokacija za CNBP
Bend6|6 D1Početak87,819,597 bp[2]
Kraj87,828,088 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
nucleic acid binding
vezivanje iona cinka
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
vezivanje iona metala
vezivanje sa DNK
single-stranded DNA binding
single-stranded RNA binding
vezivanje sa RNK
RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
mRNA binding
translation regulator activity
Ćelijska komponenta jedro
citoplazma
Endoplazmatski retikulum
citosol
Biološki proces GO:0009373 regulation of transcription, DNA-templated
cholesterol biosynthetic process
transcription, DNA-templated
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
positive regulation of cell population proliferation
GO:1901227 negative regulation of transcription by RNA polymerase II
positive regulation of cytoplasmic translation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_003418
NM_001127192
NM_001127193
NM_001127194
NM_001127195

NM_001127196

NM_001109745
NM_001109746
NM_013493
NM_001347325
NM_001355195

RefSeq (bjelančevina)
NP_001120664
NP_001120665
NP_001120666
NP_001120667
NP_001120668

NP_003409

NP_001103215
NP_001103216
NP_001334254
NP_038521
NP_001342124

Lokacija (UCSC)Chr 3: 129.17 – 129.18 MbChr 6: 87.82 – 87.83 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Funkcija

uredi

Protein ZNF9 sadrži 7 domena cinkovog prsta i vjeruje se da funkcionira kao RNK-vezujući protein. Ekspanzija CCTG u intronu 1 gena ZNF9 rezultira miotonusnom distrofijom tip 2 (MIM 602668) (upisan u OMIM).[7]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169714 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030057 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS (Oct 1990). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics. 8 (2): 411–4. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
  6. ^ Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP (Aug 2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science. 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088.
  7. ^ a b "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Dopunska literatura

uredi

Vanjski linkovi

uredi

Šablon:Transcripcijski faktori