CHSY1

CHSY1
Identifikatori
Aliasi	CHSY1
Vanjski ID-jevi	OMIM: 608183 MGI: 2681120 HomoloGene: 8950 GeneCards: CHSY1
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	101,252,048 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	65,823,546 bp
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • aktivnost sa transferazom; • acetylgalactosaminyltransferase activity; • glycosyltransferase activity; • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity; • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Ćelijska komponenta	• extracellular region; • integral component of membrane; • Golđijev aparat; • Golđijeva membrana; • Golgi cisterna membrane; • membrana;
Biološki proces	• proximal/distal pattern formation; • bone morphogenesis; • cartilage development; • chondrocyte development; • negative regulation of ossification; • Sulfacija; • positive regulation of smoothened signaling pathway; • response to nutrient levels; • chondroitin sulfate biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	22856
	269941
	ENSG00000131873
	ENSMUSG00000032640
	Q86X52
	Q6ZQ11
	NM_014918
	NM_001081163
	NP_055733
	NP_001074632
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hondroitin-sulfat sintaza 1 je enzim koji je kod ljudi kodiran genom CHSY1.^[5]^[6]

CHSY1 kodira sintetezu hondroitin-sulfata, glikozaminoglikanske ekspresije na površini većine ćelija i u vanćelijskim matriksima. Glikozamoglikonski lanci kovalentno su povezani sa širokim spektrom jezgra porodice proteina i regulišu mnoge biološke procese, uključujući proliferaciju ćelija i prepoznavanje, taloženja vanćelijskog matriksa i morfogeneze.^[6]^[7]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 802 aminokiseline, a molekulska težina 91 784 Da.^[8]

10	20	30	40	50
MAARGRRAWL	SVLLGLVLGF	VLASRLVLPR	ASELKRAGPR	RRASPEGCRS
GQAAASQAGG	ARGDARGAQL	WPPGSDPDGG	PRDRNFLFVG	VMTAQKYLQT
RAVAAYRTWS	KTIPGKVQFF	SSEGSDTSVP	IPVVPLRGVD	DSYPPQKKSF
MMLKYMHDHY	LDKYEWFMRA	DDDVYIKGDR	LENFLRSLNS	SEPLFLGQTG
LGTTEEMGKL	ALEPGENFCM	GGPGVIMSRE	VLRRMVPHIG	KCLREMYTTH
EDVEVGRCVR	RFAGVQCVWS	YEMQQLFYEN	YEQNKKGYIR	DLHNSKIHQA
ITLHPNKNPP	YQYRLHSYML	SRKISELRHR	TIQLHREIVL	MSKYSNTEIH
KEDLQLGIPP	SFMRFQPRQR	EEILEWEFLT	GKYLYSAVDG	QPPRRGMDSA
QREALDDIVM	QVMEMINANA	KTRGRIIDFK	EIQYGYRRVN	PMYGAEYILD
LLLLYKKHKG	KKMTVPVRRH	AYLQQTFSKI	QFVEHEELDA	QELAKRINQE
SGSLSFLSNS	LKKLVPFQLP	GSKSEHKEPK	DKKINILIPL	SGRFDMFVRF
MGNFEKTCLI	PNQNVKLVVL	LFNSDSNPDK	AKQVELMRDY	RIKYPKADMQ
ILPVSGEFSR	ALALEVGSSQ	FNNESLLFFC	DVDLVFTTEF	LQRCRANTVL
GQQIYFPIIF	SQYDPKIVYS	GKVPSDNHFA	FTQKTGFWRN	YGFGITCIYK
GDLVRVGGFD	VSIQGWGLED	VDLFNKVVQA	GLKTFRSQEV	GVVHVHHPVF
CDPNLDPKQY	KMCLGSKAST	YGSTQQLAEM	WLEKNDPSYS	KSSNNNGSVR
TA

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
^ ^a ^b "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".
^ supplied by OMIM
^ "UniProt, Q86X52" (jezik: англ.). Pristupljeno 13. 7. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura uredi

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization". J. Biol. Chem. 278 (41): 39711–25. doi:10.1074/jbc.M304421200. PMID 12907687.
Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J. Biol. Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

Vanjski linkovi uredi

Lokacija ljudskog genoma CHSY1 i stranica sa detaljima o genu CHSY1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131873 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032640 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11514575-5] Kitagawa H, Uyama T, Sugahara K (Oct 2001). "Molecular cloning and expression of a human chondroitin synthase". J Biol Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.

[entrez-6] "Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1".

[7] supplied by OMIM

[UniProt-8] "UniProt, Q86X52" (jezik: англ.). Pristupljeno 13. 7. 2021.CS1 održavanje: nepoznati jezik (link)

[5]

[6]

[1]

[2]

[3]

[4]

[7]

[8]