MLF1IP

(Preusmjereno sa CENPU)

Centromerni protein U jest protein koji je kod ljudi kodiran genom CENPU sa hromosoma 4.[5][6][7][8]

MLF1IP
Identifikatori
AliasiCENPU
Vanjski ID-jeviOMIM: 611511 MGI: 1919126 HomoloGene: 11629 GeneCards: CENPU
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za MLF1IP
Genomska lokacija za MLF1IP
Bend4q35.1Početak184,694,085 bp[1]
Kraj184,734,130 bp[1]
Lokacija gena (miš)
Hromosom 8 (miš)
Hrom.Hromosom 8 (miš)[2]
Hromosom 8 (miš)
Genomska lokacija za MLF1IP
Genomska lokacija za MLF1IP
Bend8|8 B1.1Početak47,005,063 bp[2]
Kraj47,033,042 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta hromosom
citoplazma
citosol
Primarno suženje
jedro
kinetohor
nukleoplazma
centar organizacije mikrotubula
Biološki proces chordate embryonic development
GO:0022415 viral process
GO:0009373 regulation of transcription, DNA-templated
GO:0061641 CENP-A containing chromatin assembly
transcription, DNA-templated
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_024629

NM_027973
NM_001368403

RefSeq (bjelančevina)

NP_078905

NP_082249
NP_001355332

Lokacija (UCSC)Chr 4: 184.69 – 184.73 MbChr 8: 47.01 – 47.03 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 47.522 Da.[9]

1020304050
MAPRGRRRPRPHRSEGARRSKNTLERTHSMKDKAGQKCKPIDVFDFPDNS
DVSSIGRLGENEKDEETYETFDPPLHSTAIYADEEEFSKHCGLSLSSTPP
GKEAKRSSDTSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRK
VKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENL
AIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKE
LNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLT
NLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSS
LRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGA
ESHLRNINHQLEKLLDQG

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
  6. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (maj 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  7. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (maj 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  8. ^ "Entrez Gene: MLF1IP MLF1 interacting protein".
  9. ^ "UniProt, Q71F23" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura

uredi