CDC123

CDC123
Identifikatori
Aliasi	CDC123
Vanjski ID-jevi	OMIM: 617708 MGI: 2138811 HomoloGene: 4394 GeneCards: CDC123
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	12,250,589 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	5,849,975 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	8872
	98828
	ENSG00000151465
	ENSMUSG00000039128
	O75794
	Q8CII2
	NM_006023
	NM_133837; NM_001356501; NM_001356502; NM_001356503; NM_001356504
	NP_006014
	NP_598598; NP_001343430; NP_001343431; NP_001343432; NP_001343433
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homologni protein 123 ciklusa ćelijske diobe je protein koji je klod ljudi kodiran genom CDC123.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 336 aminokiselina, а molekulska težina 39.135^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKKEHVLHCQ	FSAWYPFFRG	VTIKSVILPL	PQNVKDYLLD	DGTLVVSGRD
DPPTHSQPDS	DDEAEEIQWS	DDENTATLTA	PEFPEFATKV	QEAINSLGGS
VFPKLNWSAP	RDAYWIAMNS	SLKCKTLSDI	FLLFKSSDFI	TRDFTQPFIH
CTDDSPDPCI	EYELVLRKWC	ELIPGAEFRC	FVKENKLIGI	SQRDYTQYYD
HISKQKEEIR	RCIQDFFKKH	IQYKFLDEDF	VFDIYRDSRG	KVWLIDFNPF
GEVTDSLLFT	WEELISENNL	NGDFSEVDAQ	EQDSPAFRCT	NSEVTVQPSP
YLSYRLPKDF	VDLSTGEDAH	KLIDFLKLKR	NQQEDD

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151465 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039128 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bieganowski P, Shilinski K, Tsichlis PN, Brenner C (Oct 2004). "Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance". J Biol Chem. 279 (43): 44656–66. doi:10.1074/jbc.M406151200. PMID 15319434.
^ "Entrez Gene: CDC123 cell division cycle 123 homolog (S. cerevisiae)".
^ "UniProt, O75794". Pristupljeno 31. 8. 2021.

Dopunska literatura uredi

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Okuda A, Kimura G (1996). "An amino acid change in novel protein D123 is responsible for temperature-sensitive G1-phase arrest in a mutant of rat fibroblast line 3Y1". Exp. Cell Res. 223 (2): 242–9. doi:10.1006/excr.1996.0078. PMID 8601400.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Onisto M, Zeilante P, Scannapieco P, et al. (1998). "Expression study on D123 gene product: evidence for high positivity in testis". Exp. Cell Res. 242 (2): 451–9. doi:10.1006/excr.1998.4074. PMID 9683532.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi uredi

Lokacija ljudskog genoma CDC123 i stranica sa detaljima o genu CDC123 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151465 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039128 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15319434-5] Bieganowski P, Shilinski K, Tsichlis PN, Brenner C (Oct 2004). "Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance". J Biol Chem. 279 (43): 44656–66. doi:10.1074/jbc.M406151200. PMID 15319434.

[entrez-6] "Entrez Gene: CDC123 cell division cycle 123 homolog (S. cerevisiae)".

[UniProt-7] "UniProt, O75794". Pristupljeno 31. 8. 2021.

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