CCT6A

CCT6A
Identifikatori
Aliasi	CCT6A
Vanjski ID-jevi	OMIM: 104613 MGI: 107943 HomoloGene: 1336 GeneCards: CCT6A
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	56,063,989 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	129,875,212 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein folding chaperone activity; • nucleotide binding; • WD40-repeat domain binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • unfolded protein binding; • vezivanje sa RNK;
Ćelijska komponenta	• TRiC; • Mikrotubula; • Egzosom; • GO:0005578 Vanćelijski matriks; • citoplazma; • citosol;
Biološki proces	• positive regulation of establishment of protein localization to telomere; • protein stabilization; • positive regulation of telomere maintenance via telomerase; • Savijanje proteina; • positive regulation of protein localization to Cajal body; • positive regulation of telomerase RNA localization to Cajal body; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	908
	12466
	ENSG00000146731
	ENSMUSG00000029447
	P40227
	P80317
	NM_001762; NM_001009186
	NM_009838
	NP_001009186; NP_001753
	NP_033968
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica proteina 1 T-kompleksa zeta je protein koji je kod ljudi kodira gen CCT6A.^[5]^[6]^[7]

Funkcija uredi

Ovaj gen kodira molekulski šaperon koji je član kompleksa TRiC. Ovaj kompleks sastoji se od dva identična naslagana prstena, od kojih svaki sadrži po osam različitih proteina. Nerazvijeni polipeptidi ulaze u središnju šupljinu kompleksa i savijaju se na način koji ovisi o ATP-u. Kompleks savija različite proteine, uključujući aktin i tubulin. Karakterizirane su alternativne transkripcijske spojne varijante ovog gena, koje kodiraju različite izoforme.^[7]

Interakcije uredi

Dokazano je da CCT6A interreagira sa PPP4C.^[8]^[9]

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146731 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029447 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F (august 1992). "Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA". Proc Natl Acad Sci U S A. 89 (13): 6060–4. doi:10.1073/pnas.89.13.6060. PMC 49437. PMID 1352881.
^ Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F (august 1994). "Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast". J Biol Chem. 269 (28): 18616–22. PMID 8034610.
^ ^a ^b "Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)".
^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (oktobar 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (novembar 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell. Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Dopunska literatura uredi

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
Schwartz GJ, Kittelberger AM, Segel GB (2000). "Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues". Exp. Nephrol. 8 (3): 152–60. doi:10.1159/000020663. PMID 10810232.
Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H (2005). "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays". Oncol. Rep. 14 (5): 1293–8. doi:10.3892/or.14.5.1293. PMID 16211299.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

Vanjski linkovi uredi

http://genome.ucsc.edu/cgi-bin/hgTracks?db/Human hg38 CCT6A UCSC Genome Browser v410
http://genome.ucsc.edu/cgi-bin/hgTracks?db/Human hg38 chrX:15560138-15602945 UCSC Genome Browser v410

Commons ima datoteke na temu: CCT6A

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146731 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029447 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1352881-5] Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F (august 1992). "Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA". Proc Natl Acad Sci U S A. 89 (13): 6060–4. doi:10.1073/pnas.89.13.6060. PMC 49437. PMID 1352881.

[pmid8034610-6] Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F (august 1994). "Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast". J Biol Chem. 269 (28): 18616–22. PMID 8034610.

[entrez-7] "Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)".

[pmid18715871-8] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (oktobar 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid16085932-9] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (novembar 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell. Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

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