ARID4B
AT-bogati protein 4B sa interaktivnim domenom jest protein koji je kod ljudi kodiran genom ARID4B sa hromosoma 1.[5][6]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 1.312 aminokiselina, a molekulska 147.809 težina Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKALDEPPYL | TVGTDVSAKY | RGAFCEAKIK | TAKRLVKVKV | TFRHDSSTVE | ||||
| VQDDHIKGPL | KVGAIVEVKN | LDGAYQEAVI | NKLTDASWYT | VVFDDGDEKT | ||||
| LRRSSLCLKG | ERHFAESETL | DQLPLTNPEH | FGTPVIGKKT | NRGRRSNHIP | ||||
| EEESSSSSSD | EDEDDRKQID | ELLGKVVCVD | YISLDKKKAL | WFPALVVCPD | ||||
| CSDEIAVKKD | NILVRSFKDG | KFTSVPRKDV | HEITSDTAPK | PDAVLKQAFE | ||||
| QALEFHKSRT | IPANWKTELK | EDSSSSEAEE | EEEEEDDEKE | KEDNSSEEEE | ||||
| EIEPFPEERE | NFLQQLYKFM | EDRGTPINKR | PVLGYRNLNL | FKLFRLVHKL | ||||
| GGFDNIESGA | VWKQVYQDLG | IPVLNSAAGY | NVKCAYKKYL | YGFEEYCRSA | ||||
| NIEFQMALPE | KVVNKQCKEC | ENVKEIKVKE | ENETEIKEIK | MEEERNIIPR | ||||
| EEKPIEDEIE | RKENIKPSLG | SKKNLLESIP | THSDQEKEVN | IKKPEDNENL | ||||
| DDKDDDTTRV | DESLNIKVEA | EEEKAKSGDE | TNKEEDEDDE | EAEEEEEEEE | ||||
| EEEDEDDDDN | NEEEEFECYP | PGMKVQVRYG | RGKNQKMYEA | SIKDSDVEGG | ||||
| EVLYLVHYCG | WNVRYDEWIK | ADKIVRPADK | NVPKIKHRKK | IKNKLDKEKD | ||||
| KDEKYSPKNC | KLRRLSKPPF | QTNPSPEMVS | KLDLTDAKNS | DTAHIKSIEI | ||||
| TSILNGLQAS | ESSAEDSEQE | DERGAQDMDN | NGKEESKIDH | LTNNRNDLIS | ||||
| KEEQNSSSLL | EENKVHADLV | ISKPVSKSPE | RLRKDIEVLS | EDTDYEEDEV | ||||
| TKKRKDVKKD | TTDKSSKPQI | KRGKRRYCNT | EECLKTGSPG | KKEEKAKNKE | ||||
| SLCMENSSNS | SSDEDEEETK | AKMTPTKKYN | GLEEKRKSLR | TTGFYSGFSE | ||||
| VAEKRIKLLN | NSDERLQNSR | AKDRKDVWSS | IQGQWPKKTL | KELFSDSDTE | ||||
| AAASPPHPAP | EEGVAEESLQ | TVAEEESCSP | SVELEKPPPV | NVDSKPIEEK | ||||
| TVEVNDRKAE | FPSSGSNSVL | NTPPTTPESP | SSVTVTEGSR | QQSSVTVSEP | ||||
| LAPNQEEVRS | IKSETDSTIE | VDSVAGELQD | LQSEGNSSPA | GFDASVSSSS | ||||
| SNQPEPEHPE | KACTGQKRVK | DAQGGGSSSK | KQKRSHKATV | VNNKKKGKGT | ||||
| NSSDSEELSA | GESITKSQPV | KSVSTGMKSH | STKSPARTQS | PGKCGKNGDK | ||||
| DPDLKEPSNR | LPKVYKWSFQ | MSDLENMTSA | ERITILQEKL | QEIRKHYLSL | ||||
| KSEVASIDRR | RKRLKKKERE | SAATSSSSSS | PSSSSITAAV | MLTLAEPSMS | ||||
| SASQNGMSVE | CR |
Funkcija uredi
Ovaj gen kodira protein sa sekvencom sličnosti sa retinoblastom-vezujućim proteinom-1. Kodirani protein je podjedinica histon-deacetilaza-ovisnog SIN3A transkripcijskog korepresorskog kompleksa, koji funkcioniše u različitim ćelijskim procesima, uključujući proliferaciju ćelija, diferencijaciju, apoptozu, onkogenezu i određivanje ćelijske sudbine Genski proizvod prepoznaje antitijelo IgG izolirano od raka dojke pacijenta i čini se da je molekulski marker povezan sa širokim spektrom ljudskih maligniteta. Karakterizirane su alternativne transkripcijske prerađene varijante koje kodiraju različite izoforme.[6]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000054267 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039219 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst. 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
- ^ a b "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".
- ^ "UniProt, Q4LE39" (jezik: en.). Pristupljeno 7. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura uredi
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
- Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
- Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Vanjski linkovi uredi
- Lokacija ljudskog genoma ARID4B i stranica sa detaljima o genu ARID4B u UCSC Genome Browseru.